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Name: 5-Bromo-2-chloropyrimidine CAS#32779-36-5
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5-Bromo-2-chloropyrimidine CAS#32779-36-5

Basic Information

Valuable Pharmaceutical Intermediate: Widely used in the synthesis of macitentan, an endothelin receptor antagonist for pulmonary hypertension treatment.

Reactive Halogenated Structure: Contains both chloro and bromo substituents, enabling versatile chemical transformations and functionalization.

High Synthetic Utility: The pyrimidine core structure supports efficient incorporation into complex drug molecules.

Supports Advanced Drug Development: Facilitates the production of targeted therapeutic agents, making it important for modern pharmaceutical research.

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product description

Product Description of 5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is a halogenated pyrimidine derivative featuring chloro and bromo substituents at the 2- and 5-positions of the ring. It is primarily used as a pharmaceutical intermediate in the synthesis of macitentan, an endothelin receptor antagonist employed in the treatment of pulmonary hypertension.

Product Applications of 5-Bromo-2-chloropyrimidine CAS#32779-36-5

5-Bromo-2-chloropyrimidine is used as a pharmaceutical intermediate in the synthesis of various drug compounds, including inhibitors. It is also utilized in cross-coupling reactions involving indium organometallic reagents with 2,5-dihalopyrimidines.

Product Information

Parameters

Melting point	73-79 °C (lit.)
Boiling point	95°C 15mm
density	1.859±0.06 g/cm3(Predicted)
Fp	95°C/15mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	-2.84±0.22(Predicted)
form	Crystalline Powder
color	Off-white to beige
Water Solubility	insoluble
BRN	507955
Stability:	Hygroscopic
InChI	InChI=1S/C4H2BrClN2/c5-3-1-7-4(6)8-2-3/h1-2H
InChIKey	XPGIBDJXEVAVTO-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(Br)C=N1
CAS DataBase Reference	32779-36-5(CAS DataBase Reference)
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/39-37/39-36
RIDADR	UN 3335
WGK Germany	3
HazardClass	IRRITANT
HS Code	29335990

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