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Silybin CAS#22888-70-6

Silybin CAS#22888-70-6

Basic Information

Primary Active Component of Silymarin:Represents 70–80% of the silymarin complex, ensuring high biological potency.


Strong Antioxidant and Anti:Inflammatory Activity – Effectively protects cells against oxidative stress and inflammation.


Broad Pharmacological Benefits:Exhibits anticancer, antidiabetic, antiviral, antimicrobial, and immunomodulatory properties.


Powerful Organ Protection:Provides significant hepatoprotective and neuroprotective effects.


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product description

Product Description of Silybin CAS#22888-70-6

Silybin, also referred to as silibinin, is the main biologically active component of the silymarin complex, accounting for approximately 70–80%, and consists of a mixture of silybin A and silybin B. Pharmacological studies have shown that silybin exhibits a wide range of biological activities, including strong antioxidant, anti-inflammatory, anticancer, antidiabetic, hepatoprotective, neuroprotective, antiviral, antimicrobial, and immunosuppressive effects.


Product Application of Silybin CAS#22888-70-6

Silibinin has been applied in various research studies, including:

Investigating its effects on the expression of genes related to chromatin regulation in prostate cancer using real-time polymerase chain reaction (RT-PCR).

Evaluating its influence on cell proliferation in platelet-derived growth factor (PDGF)–treated human Tenon’s fibroblasts (HTFs) by analyzing proliferating cell nuclear antigen (PCNA) expression and conducting water-soluble tetrazolium salt (WST-1) assays.

Examining its impact on the gene expression of stromelysin-1 (STM1), acetyl hexosamines, and collagen synthesis during the process of skin wound healing.

Studying its inhibitory activity against Escherichia coli ATP synthase.


Product Information

Parameters


Melting point164-174°C
alphaD20 +11° (c = 0.25 in acetone + alcohol)
Boiling point793.0±60.0 °C(Predicted)
density1.527±0.06 g/cm3(Predicted)
storage temp.-20°C
solubilityAcetone (Sparingly), DMSO, Methano (Sparingly)
formSolid
pkapKa 6.42±0.04 (Uncertain)
colorPale Yellow
Water Solubility54mg/L(24.99 ºC)
Merck138607
Stability:Stable. Incompatible with strong oxidizing agents, strong bases.
LogP4.232 (est)
CAS DataBase22888-70-6(CAS DataBase Reference)
Reference
Hazard CodesXi
Risk Statements36/37/38
Safety Statements26-37/39-24/25-22-36
RIDADR3172
WGK Germany3
RTECSDJ2981770
HS Code29329990
ToxicityLD50 intravenous in mouse: 1056mg/kg


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