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  • Acetaminophen CAS#103-90-2
  • Acetaminophen CAS#103-90-2
  • Acetaminophen CAS#103-90-2
  • Acetaminophen CAS#103-90-2
  • Acetaminophen CAS#103-90-2

›

Acetaminophen CAS#103-90-2

Acetaminophen CAS#103-90-2

Basic Information

Analgesic & Antipyretic Effects‌：Effective pain relief and fever reduction.


Selective COX Inhibition‌：Modulates COX-2 more than COX-1 at high doses.


Metabolic Versatility‌：Generates reactive metabolites with diverse effects.


Animal Model Efficacy‌：Demonstrated therapeutic properties in vivo.


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product description

Products Description of Acetaminophen CAS#103-90-2

Acetaminophen is an analgesic/antipyretic that inhibits COX-2 (83%) and COX-1 (56%) at high 1,000 mg doses. Its toxic metabolite NAPQI causes liver injury by depleting glutathione, and it induces ferroptosis in mouse hepatocytes (reversible by ferrostatin-1). It remains effective for pain and fever relief in animal studies.


Product Applications of Acetaminophen CAS#103-90-2

Acetaminophen (Paracetamol, CAS# 103-90-2) is a non-anti-inflammatory antipyretic/analgesic. Comparable to aspirin in fever relief but weaker in pain relief, it is the top acetanilide derivative ideal for patients intolerant to carboxylic acid drugs. Used for colds and toothaches; also an organic intermediate, H₂O₂ stabilizer and photographic chemical component.

Product Information

Parameters


Melting point

168-172 °C(lit.)

Boiling point

273.17°C (rough estimate)

density

1,293 g/cm3

vapor pressure

0.008Pa at 25℃

refractive index

1.5810 (rough estimate)

Fp

11 °C

storage temp.

Inert atmosphere,Room Temperature

solubility

ethanol: soluble0.5M, clear, colorless

form

Crystals or Crystalline Powder

pka

9.86±0.13(Predicted)

color

White

Odor

odorless

PH

5.5-6.5 (H2O, 20℃)(saturated solution)

PH Range

5.5 - 6.5 (H?O, 20 °C) (saturated solution)

explosive limit

15%(V)

Water Solubility

14 g/L (20 ºC)

Merck

14,47

BRN

2208089

BCS Class

3,4

Cosmetics Ingredients Functions

SKIN CONDITIONING

InChIKey

RZVAJINKPMORJF-UHFFFAOYSA-N

LogP

1.098 at 25℃

CAS DataBase Reference

103-90-2(CAS DataBase Reference)

IARC

3 (Vol. 50, 73) 1999

NIST Chemistry Reference

Acetaminophen(103-90-2)

EPA Substance Registry System

Acetaminophen (103-90-2)


Safety Information


Hazard Codes

Xn,T,F

Risk Statements

22-36/37/38-52/53-36/38-40-39/23/24/25-23/24/25-11

Safety Statements

26-36-61-37/39-22-45-36/37-16-7

RIDADR

UN 3077 9/PG III

WGK Germany

1

RTECS

AE4200000

Autoignition Temperature

540 °C

TSCA

Yes

HazardClass

9

PackingGroup

III

HS Code

29242930

Hazardous Substances Data

103-90-2(Hazardous Substances Data)

Toxicity

LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson)


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