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  • Ceftriaxone sodium CAS#104376-79-6
  • Ceftriaxone sodium CAS#104376-79-6
  • Ceftriaxone sodium CAS#104376-79-6
  • Ceftriaxone sodium CAS#104376-79-6
  • Ceftriaxone sodium CAS#104376-79-6

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Ceftriaxone sodium CAS#104376-79-6

Ceftriaxone sodium CAS#104376-79-6

Basic Information

Third-Generation Broad-Spectrum Antibiotic: Ceftriaxone is a third-generation cephalosporin with broad-spectrum antibacterial activity against a wide range of pathogens.


Effective Bacterial Cell Wall Inhibition: It works by disrupting the synthesis of the peptidoglycan layer in bacterial cell walls, effectively inhibiting bacterial survival and growth.


Neuroprotective Support Function: Ceftriaxone has been shown to increase excitatory amino acid transporter-2 (EAAT2) pump expression in the central nervous system.


Reduction of Glutamatergic Toxicity: It helps reduce glutamatergic toxicity in both in vitro and in vivo models, supporting its value in neurological research applications.


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product description

Product Description of Ceftriaxone Sodium CAS#104376-79-6

Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that works by disrupting the synthesis of the peptidoglycan layer in bacterial cell walls, effectively inhibiting bacterial growth.

In addition to its antibacterial activity, ceftriaxone has been shown to enhance excitatory amino acid transporter-2 (EAAT2) expression in the central nervous system and reduce glutamatergic toxicity in both in vitro and in vivo models, highlighting its potential value in neurological research applications.


Product Application of Ceftriaxone Sodium CAS#104376-79-6

Ceftriaxone sodium (CAS#104376-79-6) belongs to the third-generation cephalosporin antibiotics. It exerts its bactericidal effect by inhibiting the synthesis of bacterial cell walls, thereby effectively killing microorganisms. It features a broad antibacterial spectrum and high stability, making it suitable for the treatment of susceptible bacterial infections in multiple systems, including the respiratory tract, urinary tract, abdominal cavity, and pelvic cavity.


Product Information

Parameters

Melting point236 °C
alphaD25 -165° (c = 1 in water) (calc for water-free substance)
refractive index-160 ° (C=1, H2O)
storage temp.Keep in dark place,Inert atmosphere,2-8°C
solubilityH2O: soluble50mg/mL
pka~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
formpowder or crystals
colorWhite to Off-White
Water SolubilityFreely soluble in water
InChIKeyFDRNWTJTHBSPMW-BBJOQENWSA-L


Safety Information


Hazard CodesXn
Risk Statements36/37/38-42/43
Safety Statements26-36-45-37-24-22
WGK Germany1
RTECSXI0368800
HS Code29349990
ToxicityLD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman)
ProviderLanguage
SigmaAldrichEnglish


Ceftriaxone sodium Usage And Synthesis


DescriptionCeftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.
Chemical PropertiesWhite Crystalline Solid
Usesantipsychotic
UsesA potentially useful antibacterial agent for proteomics research.
UsesAn antibacterial, a third-generation cephalosporin.
DefinitionChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin.
Brand nameRocephin (Roche).
Biological Activityβ -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.


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