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Sulfadiazine CAS#68-35-9

Sulfadiazine CAS#68-35-9

Basic Information

Broad-Spectrum Antimicrobial Activity: Sulfadiazine is effective against a wide range of sensitive bacteria and microorganisms, including streptococci, staphylococci, E. coli, Chlamydia, and Toxoplasma.


Effective Inhibition of Bacterial Growth: By blocking folic acid synthesis in bacterial cells, it effectively suppresses bacterial growth and reproduction.


Targeted Mechanism of Action: Its structure is similar to PABA, allowing it to competitively inhibit dihydrofolate synthase and interfere with essential nucleic acid synthesis.


Widely Used Clinical Anti-Infective Agent: As a well-established sulfonamide anti-infective drug, it is commonly used in clinical applications and pharmaceutical formulations.


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product description

Product Description of Sulfadiazine CAS#68-35-9

Sulfadiazine is a clinical sulfonamide anti-infective drug. It competitively inhibits bacterial folic acid synthesis by mimicking PABA, blocking DNA production and bacterial growth. It is active against a wide range of bacteria and other microorganisms including chlamydia, plasmodium and toxoplasma.


Product Application of Sulfadiazine CAS#68-35-9

Sulfadiazine is a potent sulfonamide antibacterial with rapid absorption, slow excretion and high blood levels. It treats a wide range of bacterial infections including meningitis, respiratory and urinary tract infections, acting by inhibiting bacterial folic acid synthesis. It also provides astringent effects in pharmaceutical applications.

Product Information

Parameters


Melting point253 °C (dec.) (lit.)
Boiling point512.6±52.0 °C(Predicted)
density1.3780 (rough estimate)
refractive index1.6440 (estimate)
storage temp.2-8°C
solubilitySoluble in dimethyl sulfoxide.
pkpKa 2.21(H2O t = 25 I = 0.5 (NaCl)) (Uncertain)
formpowder
colorwhite
Water Solubility67.13mg/L(25 ºC)
Merck148903
BRN6733588
BCS Class45750
CAS DataBase Reference68-35-9(CAS DataBase Reference)
NIST Chemistry ReferenceSulfadiazine(68-35-9)
EPA Substance Registry SystemBenzenesulfonamide, 4-amino-N-2-pyrimidinyl- (68-35-9)


Safety Information


Hazard CodesXn,Xi
Risk Statements22-36/37/38-42/43-43-42
Safety Statements26-36
RIDADR3249
WGK Germany3
RTECSWP1925000
F10
TSCAYes
HazardClass6.1(b)
PackingGroupIII
HS Code29335990
ToxicityLD50 oral in mouse: 1500mg/kg


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